| Person | Type | Job | Role(s) | Episodes |
|---|---|---|---|---|
 Gábor Csupó | Crew | Creator | Creator | 68 |
 Paul Germain | Crew | Creator | Creator | 68 |
 Anna Chlumsky | Cast | Actress | Charlotte Pickles (voice) | 72 |
 Charlie Adler | Cast | Actor | Graham (voice) | 4 |
 Cheryl Chase | Cast | Actress | Angelica Pickles (voice) | 72 |
 Cree Summer | Cast | Actress | Susie Carmichael (voice) | 72 |
 Elizabeth Daily | Cast | Actress | Tommy Pickles (voice) | 72 |
 Fred Tatasciore | Cast | Actor | Evil Doorman / Talking Screwdriver (voice) | 1 |
 Gary Anthony Williams | Cast | Actor | Booth Operator / Henchman (voice) | 1 |
 Grey DeLisle | Cast | Actress | Begley (voice) | 3 |
 Henry Winkler | Cast | Actor | Boris / The Count / Mr. Friend Doll (voice) | 1 |
 Jenifer Lewis | Cast | Actress | Ms. Marjorie (voice) | 1 |
 Kath Soucie | Cast | Actress | Phil DeVille / Lil DeVille (voice) | 72 |
 Keith Carradine | Cast | Actor | Bob Brine (voice) | 1 |
 Michael McKean | Cast | Actor | Grandpa Lou Pickles (voice) | 72 |
 Morgan Fairchild | Cast | Actress | Glammed-Up Woman (voice) | 1 |
 Nancy Cartwright | Cast | Actress | Chuckie Finster (voice) | 72 |
 Omar Benson Miller | Cast | Actor | Randy Carmichael (voice) | 72 |
 Swoosie Kurtz | Cast | Actress | Minka / Frau Klump (voice) | 1 |
 Telma Hopkins | Cast | Actress | Celeste (voice) | 2 |
 Tony Hale | Cast | Actor | Chas Finster (voice) | 72 |
 Trevor Devall | Cast | Actor | Narrator (voice) | 1 |
 Antony Del Rio | Cast | Jonathan / Jonathanicorn (voice) | 1 | |
 James Adomian | Cast | Actor | Mr. Garth (voice) | 2 |
 Kimberly Brooks | Cast | Actress | Pierce (voice) | 1 |
 Marieve Herington | Cast | Actress | Theme Singer (voice) | 2 |
 Richard Ayoade | Cast | Actor | Duffy (voice) | 7 |
 Romi Dames | Cast | Actress | Kira (voice) | 1 |
 Tommy Dewey | Cast | Actor | Stu Pickles (voice) | 72 |
Tori Kelly | Cast | Actress | Cynthia (voice) | 1 |
 Ben Schwartz | Cast | Actor | Lord Crater (voice) | 1 |
 Jordin Sparks | Cast | Actress | Tabitha (voice) | 1 |
 Josh Brener | Cast | Actor | Daxton / Invisible Eater (voice) | 1 |
 Libe Barer | Cast | Actress | Jen Z (voice) | 1 |
 Natalie Morales | Cast | Actress | Betty DeVille (voice) | 72 |
 Raini Rodriguez | Cast | Actress | Gabi (voice) | 3 |
 Robbie Daymond | Cast | Actor | Bug (voice) | 1 |
 Ashleigh Murray | Cast | Actress | Eve (voice) | 5 |
 Ashley Rae Spillers | Cast | Actress | Didi Pickles (voice) | 72 |
 Jameela Jamil | Cast | Actress | Lady De-Clutter (voice) | 1 |
 Nicole Byer | Cast | Actress | Lucy Carmichael (voice) | 72 |
 Timothy Simons | Cast | Actor | Drew Pickles (voice) | 72 |
 Ozioma Akagha | Cast | Actress | Jade O’Neil (voice) | 1 |
 Charlet Chung | Cast | Actress | Kimi (voice) | 3 |
 Cristina Milizia | Cast | Actress | Nina (voice) | 2 |
 John Omohundro | Cast | Actor | Barry (voice) | 5 |
 Tata Vega | Cast | Esperanza (voice) | 1 | |
 Alicyn Packard | Cast | Actress | Josh (voice) | 3 |
Joleen Belle | Cast | Fish (voice) | 1 | |
| Person | Type | Job | Role(s) | Episodes |
