| Person | Type | Job | Role(s) | Episodes |
|---|---|---|---|---|
 Alan Burnett | Crew | Writing | Story, Teleplay | 3 |
 Bobby Farrelly | Crew | Production | Executive Producer | 26 |
 Doug Langdale | Crew | Writing | Writer, Teleplay, Story | 2 |
 Gene Grillo | Crew | Writing | Writer | 3 |
Ginny McSwain | Crew | Production | Casting | 26 |
John Loy | Crew | Writing | Writer | 1 |
 John P. McCann | Crew | Writing | Teleplay, Writer | 1 |
Len Uhley | Crew | Writing | Writer | 5 |
Marc Hyman | Crew | Writing | Story | 1 |
 Paul Dini | Crew | Writing | Story | 1 |
 Peter Farrelly | Crew | Production | Executive Producer | 26 |
 Randall Crissman | Crew | Sound | Original Music Composer | 26 |
 Zak Penn | Crew | Production | Executive Producer | 13 |
Craig A. Williams | Crew | Writing | Writer | 1 |
Evan Gore | Crew | Writing | Writer | 2 |
Heather Lombard | Crew | Writing | Writer | 2 |
Joe Piscatella | Crew | Writing | Writer | 1 |
John Behnke | Crew | Writing | Writer | 1 |
Rob Humphrey | Crew | Writing | Writer | 1 |
Dennis Woodyard | Crew | Directing | Director | 13 |
Del Barras | Crew | Directing | Director | 13 |
Micah Wright | Crew | Writing | Writer | 1 |
Steven Darancette | Crew | Writing | Writer | 1 |
Ray DeLaurentis | Crew | Writing | Writer | 2 |
Guen-Sik Song | Crew | Directing | Director | 1 |
Marc Gutman | Crew | Writing | Writer, Teleplay | 2 |
 Alanna Ubach | Cast | Actress | Mayor Paul Spryman / Hector's Mom (voice) | 26 |
 Andrea Martin | Cast | Actress | Aunti Histamine (voice) | 1 |
 April Winchell | Cast | Actress | Cafeteria Lady (voice) | 1 |
 Billy West | Cast | Actor | Muscle Cell (voice) | 1 |
 Brad Garrett | Cast | Actor | Strepfinger (voice) | 2 |
 Brian Posehn | Cast | Actor | Sylvian Fisher (voice) | 1 |
 Candi Milo | Cast | Actress | Mumsy Glop (voice) | 1 |
 Charlie Adler | Cast | Actor | General Malaise / Dr. Hammertoe (voice) | 1 |
 Cree Summer | Cast | Actress | Mayor Santorini (voice) | 2 |
 Danny Bonaduce | Cast | Actor | Smirch (voice) | 1 |
Danny Cooksey | Cast | Actor | Shane (voice) | 1 |
 Danny Mann | Cast | Actor | Rudy (voice) | 1 |
 Dawnn Lewis | Cast | Actress | Cilia Tyson (voice) | 2 |
 Dee Bradley Baker | Cast | Actor | Father Glop (voice) | 1 |
 Frank Welker | Cast | Actor | Billy Blob Bile (voice) | 1 |
 Henry Winkler | Cast | Actor | Sal Monella (voice) | 1 |
 Hope Levy | Cast | Actress | Brittany Estrogen (voice) | 1 |
 Jeff Bennett | Cast | Actor | Drix (voice) | 26 |
 Jeffrey Garcia | Cast | Actor | Ricardo Amino (voice) | 1 |
 Jeffrey Tambor | Cast | Actor | The Mole (voice) | 3 |
 Jess Harnell | Cast | Actor | Shwee (voice) | 1 |
 Jim Belushi | Cast | Actor | Captain Quinine (voice) | 1 |
 Jim Cummings | Cast | Actor | Police Chief Gluteus (voice) | 26 |
 Joe Lala | Cast | Actor | Hector's Dad (voice) | 2 |
 Julian Sands | Cast | Actor | Penicillin G (voice) | 1 |
 Justin Cowden | Cast | Actor | Hector Cruz (voice) | 26 |
 Justine Bateman | Cast | Actress | Rota (voice) | 1 |
 Kath Soucie | Cast | Actress | Naurine / Celly Katz (voice) | 1 |
 Kathy Najimy | Cast | Actress | Loretta Epstein (voice) | 1 |
 Kevin Michael Richardson | Cast | Actor | Rescue Cell (voice) | 3 |
 Miriam Flynn | Cast | Actress | Drixeen (voice) | 1 |
 Neil Ross | Cast | Actor | Cop (voice) | 1 |
 Pat Fraley | Cast | Actor | Nerve Cell General (voice) | 1 |
 Phil LaMarr | Cast | Actor | Osmosis Jones (voice) | 26 |
 Rino Romano | Cast | Actor | Jude (voice) | 1 |
 Rob Paulsen | Cast | Actor | Stickety Lipid (voice) | 1 |
 Roger Rose | Cast | Actor | Jumbo (voice) | 1 |
 Susan Silo | Cast | Actress | Cryo (voice) | 1 |
 Tara Strong | Cast | Actress | Ashley / Carbon Monoxide (voice) | 1 |
 Tasia Valenza | Cast | Actress | Maria Amino (voice) | 26 |
 Tim Curry | Cast | Actor | Nick O'Teen (voice) | 1 |
 Vivica A. Fox | Cast | Actress | Ellen Patella (voice) | 6 |
 Wendie Malick | Cast | Actress | Number 2 / Sticky Flagella (voice) | 1 |
 Kimberly Brooks | Cast | Actress | Christine Kolchuck (voice) | 3 |
| Person | Type | Job | Role(s) | Episodes |
