| Person | Type | Job | Role(s) | Episodes |
|---|---|---|---|---|
 John Mulaney | Crew | Creator | Creator | |
 Adria Tennor | Cast | Actress | Flight Attendant | 1 |
 Ayumi Iizuka | Cast | Actress | Mother | 1 |
 Ben Lawson | Cast | Actor | Greg | 1 |
 Bunny Levine | Cast | Actress | Old Woman | 1 |
 Carole Goldman | Cast | Actress | Mrs. Tuchman | 2 |
 Dan Levy | Cast | Actor | Dad (voice) | 1 |
 Dean Cain | Cast | Actor | Dean Cain | 1 |
 Duane R. Shepard Sr. | Cast | Actor | Percy | 1 |
 Eddie Pepitone | Cast | Actor | Arnie | 1 |
 Elliott Gould | Cast | Actor | Oscar | 13 |
 Greta Sesheta | Cast | Actress | Cantor | 1 |
 Irene Roseen | Cast | Actress | Mrs. Regenbogen | 1 |
 Jack Axelrod | Cast | Actor | Elderly Veteran | 1 |
 James Handy | Cast | Actor | Father Ed | 1 |
 Jamie Denbo | Cast | Actress | Sharisse | 1 |
 Jerry Minor | Cast | Actor | Murphy | 1 |
 Kareem J. Grimes | Cast | Actor | Audience Member | 1 |
 Karey Dornetto | Cast | Brenda | 1 | |
 Keisuke Hoashi | Cast | Actor | Dr. Cho | 1 |
 Lorraine Bracco | Cast | Actress | Vaughn | 1 |
 Lyle Kanouse | Cast | Actor | Teamster | 1 |
 Maria Christina Thayer | Cast | Actress | Amanda | 1 |
 Martin Short | Cast | Actor | Lou | 13 |
 Molly Shannon | Cast | Actress | Markie | 1 |
 Nora Dunn | Cast | Actress | Patty Mulaney | 1 |
 Penny Marshall | Cast | Actress | Tutti | 1 |
 Rocky McMurray | Cast | Actor | Recruiter | 1 |
 Sonya Eddy | Cast | Actress | Gerta | 1 |
 Bailee Madison | Cast | Actress | Ruby | 1 |
 Brooke Lyons | Cast | Actress | Cassidy | 1 |
 Danielle Moné Truitt | Cast | Actress | Girl | 1 |
 Frankie Shaw | Cast | Actress | Julia | 1 |
John Mulaney | Cast | Actor | John | 13 |
 Joy Osmanski | Cast | Actress | Alexa | 1 |
 Kamala Jones | Cast | Actress | Hot Blonde | 1 |
 Kristi Clainos | Cast | Actress | Girl | 1 |
 Laura Bailey | Cast | Actress | Narrator (voice) | 1 |
 Leonard Jackson | Cast | Actor | Crew Member | 1 |
 Nasim Pedrad | Cast | Actress | Jane | 13 |
 Natasha Leggero | Cast | Actress | Rodeo | 1 |
 Nick Kroll | Cast | Actor | Jesse Tyler Munoz | 1 |
 Robert Baker | Cast | Actor | Chad | 1 |
 Art Napiontek | Cast | Actor | Ripped Andre | 1 |
 Bechir Sylvain | Cast | Actor | Bobby | 1 |
 Corey Martin Craig | Cast | Actor | Young Man | 1 |
 Danielle Kaplowitz | Cast | Woman | 1 | |
 Leena Huff | Cast | Actress | Girl | 1 |
 Lordan Napoli | Cast | Actress | Stacy (voice) | 1 |
 Megan Heyn | Cast | Kristen | 1 | |
 Pete Holmes | Cast | Actor | Father Trey | 1 |
 Ron Funches | Cast | Actor | Rodney | 1 |
 Tess Paras | Cast | Actress | Female Contestant | 1 |
 Barak Hardley | Cast | Actor | Paul | 1 |
 Fortune Feimster | Cast | Actress | Mary Jo | 3 |
 Scott Broderick | Cast | Actor | Audience Member | 1 |
 Zack Pearlman | Cast | Actor | Andre | 13 |
 Nico Santos | Cast | Actor | Contestant | 1 |
 Julie Klausner | Cast | Donna | 3 | |
 Thomas Crawford | Cast | Actor | French Waiter | 1 |
 Tanner Flood | Cast | Actor | Young Mulaney | 1 |
 J.M. Longoria | Cast | Actor | Photographer | 1 |
 Seaton Smith | Cast | Motif | 13 | |
 Tessa Goss | Cast | Actress | News Anchor | 2 |
 Kayla Maisonet | Cast | Actress | Teen Girl | 1 |
 Brennan Feonix | Cast | Actor | Audience Member | 1 |
 David Theune | Cast | Actor | Stage Manager | 1 |
 Christopher Kager | Cast | Contestant | 1 | |
 Victoria Grace | Cast | Actress | Teen | 1 |
Liz Porter | Cast | Actress | Dancer | 1 |
 Ron G. | Cast | Darren | 1 | |
Leon Simmons | Cast | Actor | Ernie | 1 |
Bruce M. Stockert | Cast | Actor | Man at Bris | 1 |
Edward Enriquez-Cohen | Cast | Stage Hand O.C. | 1 | |
 Jen Reiter | Cast | Casting Director O.C. | 1 | |
 Dan Mintz | Cast | Actor | Mintz | 1 |
| Person | Type | Job | Role(s) | Episodes |
