| Person | Type | Job | Role(s) | Episodes |
|---|---|---|---|---|
 Al Goto | Crew | Crew | Stunt Coordinator | 1 |
 Alan Silvestri | Crew | Sound | Original Music Composer | 26 |
 André Bormanis | Crew | Writing | Writer, Consulting Producer | 1 |
 Ann Druyan | Crew | Art | Creative Director, Executive Producer | 1 |
 Bill Pope | Crew | Camera | Director of Photography, Director | 13 |
 Brannon Braga | Crew | Production | Executive Producer, Writer | 13 |
 Carl Sagan | Crew | Writing | Writer | 13 |
 Eric A. Sears | Crew | Editing | Editor | 13 |
Eric Lea | Crew | Editing | Editor | 13 |
 Jason Clark | Crew | Production | Producer | 13 |
Jeffrey A. Okun | Crew | Visual Effects | Visual Effects Supervisor | 6 |
John Duffy | Crew | Editing | Editor | 26 |
 Karl Walter Lindenlaub | Crew | Camera | Director of Photography | 13 |
Martin Nicholson | Crew | Editing | Editor | 1 |
Michael O'Halloran | Crew | Editing | Editor | 13 |
 Mitchell Cannold | Crew | Production | Executive Producer | 13 |
Miye 'Mimi' Matsumoto | Crew | Costume & Make-Up | Key Costumer | 1 |
Neil Greenberg | Crew | Visual Effects | VFX Editor | 3 |
Randy E. Moore | Crew | Crew | Special Effects Coordinator | 5 |
 Ruth E. Carter | Crew | Costume & Make-Up | Costume Designer | 7 |
 Seth MacFarlane | Crew | Production | Executive Producer | 13 |
 Zack Grobler | Crew | Art | Production Design | 7 |
Dustin DellaVecchia | Crew | Production | Production Coordinator | 3 |
 Shahrzad Davani | Crew | Directing | Assistant Director | 3 |
Mara Herdmann | Crew | Directing | Script Supervisor | 10 |
Mark J. Levenstein | Crew | Production | Researcher | 2 |
 Steven Soter | Crew | Writing | Writer, Creator | 13 |
Ian Scroggins | Crew | Art | Art Direction | 6 |
Fawn McDonald | Crew | Production | Production Coordinator | 2 |
Jane Day | Crew | Costume & Make-Up | Assistant Costume Designer | 3 |
 Corran Brownlee | Crew | Visual Effects | Animation Director | 13 |
Steven Holtzman | Crew | Production | Producer | 13 |
Jack Geist | Crew | Visual Effects | Visual Effects Producer | 7 |
Adam Druxman | Crew | Directing | Assistant Director | 6 |
J.D. Sievertson | Crew | Editing | Assistant Editor | 1 |
Kate Vanderbyl | Crew | Directing | Second Assistant Director | 2 |
Peter Tackaberry | Crew | Editing | Assistant Editor | 1 |
Alysse Leite-Rogers | Crew | Directing | First Assistant Director | 2 |
Livia Hanich | Crew | Production | Producer | 13 |
David Bifano | Crew | Sound | Music Producer | 2 |
Josh Mason | Crew | Production | Production Supervisor | 3 |
Coby Greenberg | Crew | Directing | Second Unit Director, Co-Producer | 13 |
Tomas Sanchez | Crew | Crew | Stunt Coordinator | 5 |
Lucas Gray | Crew | Visual Effects | Supervising Animation Director | 1 |
Andrew Brandou | Crew | Visual Effects | Animation Director | 4 |
Aiden Arata | Crew | Directing | Script Coordinator | 7 |
 Alan Shearman | Cast | Actor | (voice) | 1 |
Alan Silvestri | Cast | Actor | Self | 1 |
 Alexander Siddig | Cast | Actor | Isaac Newton (voice) | 1 |
 Alfred Molina | Cast | Actor | Ibn al-Haytham (voice) | 1 |
 Andrew Pifko | Cast | Actor | (voice) | 1 |
André Bormanis | Cast | Actor | Self | 1 |
 André Sogliuzzo | Cast | Actor | Weichelberger (voice) | 1 |
 Bill Nye | Cast | Actor | Self | 1 |
Bill Pope | Cast | Actor | Self | 1 |
Brannon Braga | Cast | Actor | World's Fair Attendee | 1 |
Carl Sagan | Cast | Actor | Self (voice) (archive footage) | 2 |
 Cary Elwes | Cast | Actor | Edmond Halley / Robert Hooke (voice) | 1 |
 Christiane Amanpour | Cast | Actress | Enheduanna (voice) | 1 |
 Christopher Emerson | Cast | Actor | Acolyte (voice) | 1 |
 Edita Brychta | Cast | Actress | (voice) | 1 |
 Eliza Schneider | Cast | Actress | (voice) | 1 |
 Enn Reitel | Cast | Actor | 1 | |
 Fay Masterson | Cast | Actress | (voice) | 1 |
 Fred Tatasciore | Cast | Actor | Democritus (voice) | 1 |
 Heiko Obermöller | Cast | Actor | Einstein's Father (voice) | 1 |
Jason Clark | Cast | Actor | Self | 1 |
 John F. Kennedy | Cast | Actor | Self (voice) (archive footage) | 1 |
 Judd Hirsch | Cast | Actor | Robert Oppenheimer (voice) | 1 |
 Kara Vallow | Cast | Actress | Self | 1 |
 Keythe Farley | Cast | Actor | (voice) | 1 |
 Kirsten Dunst | Cast | Actress | Cecilia Payne (voice) | 1 |
 Larry Cedar | Cast | Actor | 1 | |
 Marc Worden | Cast | Actor | Harrison Brown (voice) | 1 |
 Marcelo Tubert | Cast | Actor | (voice) | 1 |
 Marlee Matlin | Cast | Actress | Annie Jump Cannon (voice) | 1 |
 Martin Jarvis | Cast | Actor | Humphry Davy (voice) | 1 |
 Masasa Moyo | Cast | Actress | 1 | |
 Michael McConnohie | Cast | Actor | 1 | |
Mitchell Cannold | Cast | Actor | Self | 1 |
 Nick Jameson | Cast | Actor | 1 | |
 Nick Sagan | Cast | Actor | 1 | |
 Olivia d'Abo | Cast | Actress | Marie Curie (voice) | 1 |
 Patrick Stewart | Cast | Actor | William Herschel (voice) | 2 |
 Paul Sorvino | Cast | Actor | Augustin Mouchot (voice) | 1 |
 Phil Crowley | Cast | Actor | (voice) | 1 |
 Rainer Gombos | Cast | Self | 1 | |
 Richard Gere | Cast | Actor | Clair Patterson (voice) | 1 |
Seth MacFarlane | Cast | Actor | Sherwood Rowland (voice) | 1 |
 Seth Reed | Cast | Actor | Self | 1 |
 Steve Oatway | Cast | Charles Darwin | 1 | |
 Stoney Emshwiller | Cast | Actor | 1 | |
 Tom Konkle | Cast | Actor | Samuel Pepys (voice) | 1 |
 Viggo Mortensen | Cast | Actor | Nikolai Vavilov (voice) | 1 |
 William Salyers | Cast | Actor | (voice) | 1 |
 Yuri Lowenthal | Cast | Actor | (voice) | 1 |
 Amanda Seyfried | Cast | Actress | Marie Tharp (voice) | 1 |
 Christopher Lee Parson | Cast | Actor | (voice) | 1 |
 Julian Ovenden | Cast | Actor | Michael Faraday (voice) | 1 |
 Ken Lally | Cast | Actor | (voice) | 1 |
 Neil deGrasse Tyson | Cast | Actor | Self | 3 |
 Oliver Vaquer | Cast | Actor | Joseph von Fraunhofer (voice) | 1 |
 Paul Telfer | Cast | Actor | Angry Scholar #2 (voice) | 1 |
 Adam Tsekhman | Cast | Actor | Christiaan Huygens | 1 |
 Jonathan Morgan Heit | Cast | Actor | John Herschel (voice) | 1 |
 Michael Chochol | Cast | Actor | Jan Oort | 1 |
 Natasha Anne Francis | Cast | Self | 1 | |
 Piotr Michael | Cast | Actor | Edmund Muskie (voice) | 1 |
 Leandro Guedes | Cast | Young Stephen Joseph Tyson | 1 | |
 Natasha Goubskaya | Cast | Actress | (voice) | 1 |
 Frank Baxter | Cast | Actor | Self (archive footage) | 1 |
 Rick Pasqualone | Cast | Actor | (voice) | 1 |
 Brendan Bradley | Cast | Actor | (voice) | 1 |
 Joseph J. Micucci | Cast | Actor | Young Father | 1 |
 Harssh A. Singh | Cast | Ashoka (voice) | 1 | |
 John Steven Rocha | Cast | Actor | Bellaramine (voice) | 1 |
 Sasha Sagan | Cast | Actress | Rachel Molly Gruber | 3 |
 Glenn Steinbaum | Cast | Bruce Heezen (voice) | 1 | |
 Matthew Jayson Cwern | Cast | Actor | (voice) | 1 |
 Jamie Hanes | Cast | 1 | ||
 Neil Arnote | Cast | Actor | Neil Armstrong | 1 |
 Lennard Ortmann | Cast | Albert Einstein | 1 | |
 Ernie Vigil | Cast | Actor | Thomas Young | 1 |
 Marcello Guedes | Cast | Actor | Young Neil deGrasse Tyson | 1 |
 Novi Brown | Cast | Actress | (voice) | 1 |
 Peggy Jo Jacobs | Cast | Actress | Margaret Harwood (voice) | 1 |
 Carol Bach Rita | Cast | Actress | Caroline Herschel (voice) | 1 |
 Brent Woods | Cast | Actor | Self | 1 |
 Trang Vo | Cast | Actress | Birthmark Woman | 1 |
 Mara Junot | Cast | Actress | (voice) | 1 |
 Alex Bartram | Cast | Actor | Samuel Sagan | 1 |
 Elijah Braik | Cast | Actor | (voice) | 1 |
Maria Frucci | Cast | 1 | ||
 Noah Langford | Cast | (voice) | 1 | |
Jack Rainsford | Cast | (voice) | 1 | |
Masoumeh Husseini | Cast | Monk (voice) | 1 | |
 Elizardo Torrez | Cast | Young Carl Sagan | 2 | |
 Shereen Balles | Cast | Female Voyager (voice) | 1 | |
 Kapeneta Te'o-Tafiti | Cast | Male Voyager (voice) | 1 | |
 Clinnette Minnis | Cast | 1 | ||
Joseph Grange | Cast | John Herschel (voice) | 1 | |
Skye Sammoutis | Cast | (voice) | 1 | |
 Will Greenburg | Cast | John Goodricke | 1 | |
Dex de Groot | Cast | 1 | ||
Joep Fellinger | Cast | 1 | ||
Yurika Okamura | Cast | (voice) | 1 | |
Sianna Chan | Cast | (voice) | 1 | |
Selyna Chan | Cast | (voice) | 1 | |
| Person | Type | Job | Role(s) | Episodes |
