| Person | Type | Job | Role(s) |
|---|---|---|---|
 Ad Schaumer | Crew | Directing | Assistant Director |
 Arthur Conan Doyle | Crew | Writing | Novel |
 Ben Nye | Crew | Costume & Make-Up | Makeup Artist |
Bert Shefter | Crew | Sound | Original Music Composer |
 Charles Bennett | Crew | Writing | Screenplay |
Duncan Cramer | Crew | Art | Art Direction |
Helen Turpin | Crew | Costume & Make-Up | Hairstylist |
Hugh S. Fowler | Crew | Editing | Editor |
 Irwin Allen | Crew | Directing | Director, Screenplay, Producer |
John Sturtevant | Crew | Art | Set Decoration |
Joseph Kish | Crew | Art | Set Decoration |
Paul Sawtell | Crew | Sound | Original Music Composer |
Paul Zastupnevich | Crew | Costume & Make-Up | Costume Design |
Walter M. Scott | Crew | Art | Set Decoration |
Walter M. Simonds | Crew | Art | Art Direction |
 Willis H. O'Brien | Crew | Visual Effects | Visual Effects |
Winton C. Hoch | Crew | Camera | Director of Photography |
 Bert Stevens | Cast | Actor | Reporter at Airport (uncredited) |
 Bess Flowers | Cast | Actress | Guest at Zoological Institute Forum (uncredited) |
 Claude Rains | Cast | Actor | Prof. George Edward Challenger |
 Colin Campbell | Cast | Actor | Prof. Waldron (uncredited) |
 Cosmo Sardo | Cast | Actor | Guest at Zoological Institute Forum (uncredited) |
 David Hedison | Cast | Actor | Ed Malone |
 Fernando Lamas | Cast | Actor | Manuel Gomez |
 Ian Wolfe | Cast | Actor | Burton White |
 Jay Novello | Cast | Actor | Costa |
 Jill St. John | Cast | Actress | Jennifer Holmes |
John Graham | Cast | Actor | Stuart Holmes (uncredited) |
 Kenner G. Kemp | Cast | Actor | Guest at Zoological Institute Forum (uncredited) |
 Larry Chance | Cast | Actor | Indian Chief (uncredited) |
 Michael Rennie | Cast | Actor | Lord John Roxton |
 Ray Stricklyn | Cast | Actor | David Holmes |
 Richard Haydn | Cast | Actor | Prof. Summerlee |
 Vitina Marcus | Cast | Actress | Native Girl |
 Al Bain | Cast | Actor | Man at Airport (uncredited) |
Murray Pollack | Cast | Actor | Guest at Zoological Institute Forum (uncredited) |
| Person | Type | Job | Role(s) |
