| Person | Type | Job | Role(s) |
|---|---|---|---|
 Allison Abbate | Crew | Production | Producer |
 Charles Roven | Crew | Production | Executive Producer |
 Chris Columbus | Crew | Production | Executive Producer |
 Dan Povenmire | Crew | Production | Executive Producer |
 Emil Mitev | Crew | Art | Art Direction |
 Eyal Podell | Crew | Writing | Story |
Joe Haidar | Crew | Art | Storyboard Artist |
Joe Ruby | Crew | Writing | Characters |
 Tom Holkenborg | Crew | Sound | Original Music Composer |
Ken Spears | Crew | Writing | Characters |
 Matt Lieberman | Crew | Writing | Screenplay, Story |
Pam Coats | Crew | Production | Producer |
Rafael Zentil | Crew | Writing | Head of Story |
Ricardo F. Delgado | Crew | Art | Storyboard Artist |
Richard Suckle | Crew | Production | Executive Producer |
Ruth Lambert | Crew | Production | Casting |
Ryan Folsey | Crew | Editing | Editor |
Timothy Jason Smith | Crew | Production | Associate Producer |
 Tom Ruegger | Crew | Visual Effects | Visual Effects Designer, Art Designer |
 Tony Cervone | Crew | Directing | Director |
 Adam Sztykiel | Crew | Writing | Screenplay, Executive Producer |
Bill Haller | Crew | Visual Effects | Head of Animation |
Derek Elliott | Crew | Writing | Screenplay |
Jonathon E. Stewart | Crew | Writing | Story |
Michael Kurinsky | Crew | Art | Production Design |
Tony Cosanella | Crew | Production | Co-Producer |
 Gabe Hilfer | Crew | Sound | Music Supervisor |
Jack Donaldson | Crew | Writing | Screenplay |
Didier Ah-Koon | Crew | Art | Storyboard Artist |
Danelle Davenport | Crew | Art | Storyboard Artist |
Andy Horwitz | Crew | Production | Executive Producer |
Mike Fortner | Crew | Crew | CG Supervisor |
Stephen W. Childers | Crew | Camera | Head of Layout |
Vanara Taing | Crew | Editing | Editor |
 Charlie Puth | Crew | Sound | Songs |
Jesse Ehrman | Crew | Production | Executive Producer |
Tal Fishman | Crew | Art | Art Direction |
 Ava Max | Crew | Sound | Songs |
 Rico Nasty | Crew | Sound | Songs |
 Jack Harlow | Crew | Sound | Songs |
 Pink Sweat$ | Crew | Sound | Songs |
Chiranjiv Makwana | Crew | Writing | Screenplay |
Noëlle Raffaele | Crew | Writing | Story Artist |
 Billy West | Cast | Actor | Muttley (voice) |
 Christina Hendricks | Cast | Actress | Officer Jaffe (voice) |
 Don Messick | Cast | Actor | Muttley (archive audio) (voice) |
 Frank Welker | Cast | Actor | Scooby-Doo / Pterodactyl (voice) |
 Fred Tatasciore | Cast | Actor | Cerberus (voice) |
Harry Perry | Cast | Harry Perry (voice) | |
 Henry Winkler | Cast | Actor | Keith (voice) |
 Jason Isaacs | Cast | Actor | Dick Dastardly (voice) |
 John DiMaggio | Cast | Actor | Restaurant Owner (voice) |
 Justina Machado | Cast | Actress | Jamie Rivera (voice) |
 Ken Jeong | Cast | Actor | Dynomutt, Dog Wonder (voice) |
 Kevin Heffernan | Cast | Actor | Bike Cop Gary (voice) |
 Mark Wahlberg | Cast | Actor | Blue Falcon (voice) |
Pam Coats | Cast | Mrs. Rogers (voice) | |
Ryan Folsey | Cast | Actor | Beach Guy (voice) |
Tony Cervone | Cast | Actor | Ghost / Mr. Rigby / Alice (voice) |
 Tracy Morgan | Cast | Actor | Captain Caveman (voice) |
 Will Forte | Cast | Actor | Shaggy Rogers (voice) |
Adam Sztykiel | Cast | Actor | Officer Casey (voice) |
 Amanda Seyfried | Cast | Actress | Daphne Blake (voice) |
 Gina Rodriguez | Cast | Actress | Velma Dinkley (voice) |
 Ira Glass | Cast | Actor | Ira Glass (voice) |
Michael Kurinsky | Cast | Actor | Samuel Colton (voice) |
 Simon Cowell | Cast | Actor | Simon Cowell (voice) |
 Zac Efron | Cast | Actor | Fred Jones (voice) |
 Pierce Gagnon | Cast | Actor | Young Fred (voice) |
 Kiersey Clemons | Cast | Actress | Dee Dee Skyes (voice) |
 Maya Erskine | Cast | Actress | Judy Takamoto (voice) |
 Mckenna Grace | Cast | Actress | Young Daphne (voice) |
Henry Kaufman | Cast | Actor | Chad / Chet (voice) |
 Iain Armitage | Cast | Actor | Young Shaggy (voice) |
 Ariana Greenblatt | Cast | Actress | Young Velma (voice) |
Kennedy Peil | Cast | Actress | Indira Knight (voice) |
Vanara Taing | Cast | Actress | Baby Rotten (voice) |
John McDaniel | Cast | Hal Murphy (voice) | |
Alex Kauffman | Cast | Officer North (voice) | |
Sarah Lancia | Cast | Actress | Dispatcher Stevens (voice) |
Maven Morgan | Cast | Kari (voice) | |
Eric Cowell | Cast | Ben (voice) | |
| Person | Type | Job | Role(s) |
