| Person | Type | Job | Role(s) |
|---|---|---|---|
 Steve Oedekerk | Crew | Production | Executive Producer |
 Mike Gasaway | Crew | Directing | Director |
Charlie Brissette | Crew | Sound | Music |
Joseph P. Johnston | Crew | Visual Effects | Layout Supervisor |
 Alyssa Milano | Cast | Actress | April (voice) |
 Billy West | Cast | Actor | Sam / Corky Shumatsu (voice) |
 Carlos Alazraqui | Cast | Actor | Sr. Estevez (voice) |
 Carolyn Lawrence | Cast | Actress | Cindy Vortex (voice) |
 Crystal Scales | Cast | Actress | Libby Folfax (voice) |
 Debi Derryberry | Cast | Actress | Jimmy Neutron / Alien Actress / Alien Woman (voice) |
 Frank Welker | Cast | Actor | Goddard (voice) |
 Grey DeLisle | Cast | Actress | Vendanna (voice) |
 Jeff Bennett | Cast | Actor | Gorlock #2 / Brain #1 (voice) |
 Jeffrey Garcia | Cast | Actor | Sheen Estevez / Army Guard (voice) |
 Jess Harnell | Cast | Actor | Meldar Prime (singing voice) |
 Jim Cummings | Cast | Actor | Brain #2 / Mayor Quadar (voice) |
 Joe Lala | Cast | Actor | Sr. Estevez (voice) |
 Mark DeCarlo | Cast | Actor | Hugh Neutron / Emergency System / Gen. Abercrombie (voice) |
 Megan Cavanagh | Cast | Actress | Judy Neutron / Mrs. Vortex (voice) |
 Phil LaMarr | Cast | Actor | Bolbi Stroganofsky / British Tourist (voice) |
 Rob Paulsen | Cast | Actor | Carl Wheezer/Mr. Wheezer/Mrs. Wheezer/Test Pilot/Announcer (voice) |
 Tim Allen | Cast | Actor | Meldar Prime (voice) |
| Person | Type | Job | Role(s) |
