Winona Ryder is on great form here in this rather brutally frank look at a girl struggling with mental health issues. "Susanna" had been rushed to hospital by her worried parents after an apparent attempt at suicide. Diagnosed with a potential personality disorder, she is admitted to the "Claymoore" facility under the care of "Dr. Wick" (Vanessa Redgrave) and nurse "Valerie" (Whoopi Goldberg). As you'd expect, this place has a multitude of characters inside and she (and we) are introduced to a mixture ranging from the pathological liar to the anorexic, the sociopath to the schizophrenic. Some are friendlier to her, others ignore her altogether. It's "Lisa" (Angelina Jolie) whom she seems to relate to her best. She is a controlling character who swings between munificence and malevolence at the drop of an hat whilst giving the staff a constant stream of headaches. On the outside, her recently drafted boyfriend "Tobias" (Jared Leto) is trying to coax her to return to the outside world, but she seems to thrive on the institutionalised nature of her new life, addicted to it even. Gradually, though she begins to appreciate that "Lisa" is a toxic influence on her life - evidenced by a tragedy that really brings things home to her. The ensemble of patients - Clea Duvall, Brittany Murphy and Elizabeth Moss all work well with the sparingly appearing Goldberg and Redgrave to create a really affecting atmosphere here, but it's Jolie who delivers best with a career-defining effort as a creature that it's impossible to like but equally difficult not to feel sympathy for too. It's intensely scripted, occasionally funny and pretty perfectly paced and though not a easy watch, is certainly a powerful one.