| Person | Type | Job | Role(s) |
|---|---|---|---|
 Atul Tiwari | Crew | Writing | Dialogue |
 Gautami Tadimalla | Crew | Costume & Make-Up | Costume Design |
Grady Allen Bishop | Crew | Crew | Stunt Double |
 Himesh Reshammiya | Crew | Sound | Original Music Composer, Playback Singer |
 K. S. Ravikumar | Crew | Directing | Director |
 Kamal Haasan | Crew | Writing | Story, Screenplay, Dialogue, Playback Singer |
 Kanal Kannan | Crew | Crew | Stunt Coordinator |
Michael Mosher | Crew | Costume & Make-Up | Special Effects Makeup Artist |
Ralis Kahn | Crew | Costume & Make-Up | Special Effects Makeup Artist |
 Sadhana Sargam | Crew | Sound | Playback Singer |
 Vairamuthu | Crew | Writing | Lyricist |
Ashmith Kunder | Crew | Editing | Editor |
 Devi Sri Prasad | Crew | Sound | Original Music Composer |
 Ravi Varman | Crew | Camera | Director of Photography |
V. Ravichandran | Crew | Production | Producer |
Vaali | Crew | Writing | Lyricist |
Andrew Scott Dixon | Crew | Crew | Stunt Coordinator |
Thanigachalam | Crew | Editing | Editor |
M. Prabhaharan | Crew | Art | Art Direction |
 Hariharan | Crew | Sound | Playback Singer |
Mahalakshmi Iyer | Crew | Sound | Playback Singer |
 Pop Shalini | Crew | Sound | Playback Singer |
Brian Jennings | Cast | Actor | Chief of Home Land Security |
Chitti Babu | Cast | Ekambaram | |
 Jaya Prada | Cast | Actress | Ranjitha Singh |
Kamal Haasan | Cast | Actor | Govindarajan Ramaswamy / Rangaraja Nambi / George W. Bush / Avtaar Singh / Balram Naidu / Christian Fletcher / Shinghen Narahasi / Krishnaveni / Vincent Poovaragavan / Kalifullah Mukhtaar |
 Nagesh | Cast | Actor | Sheikh Mukhtaar |
 Napoleon | Cast | Actor | Kulothunga Chola II |
 P. Vasu | Cast | Actor | J. Ragavendra (Jaa Raa) |
 Santhana Bharathi | Cast | Actor | J. Ragavendra's brother-in-law |
 Asin Thottumkal | Cast | Actress | Kodhai Radha / Andal |
 David W. Scott | Cast | Actor | Lab Tech / Detective |
 M. S. Bhaskar | Cast | Actor | Broadway Kumar |
 Mallika Sherawat | Cast | Actress | Jasmine |
 R. Sundarrajan | Cast | Actor | Member of Legislative Assembly |
 Vaiyapuri | Cast | Actor | Prabhu |
 Chakri Toleti | Cast | Actor | Sairam |
Raghuram | Cast | Actor | Appa Rao |
Shammu | Cast | Assistant Biotechnologist | |
 Rekha | Cast | Actress | Meenakshi Ragavendra |
 Ramesh Khanna | Cast | Actor | Doctor |
 K R Vijaya | Cast | Actress | Megha Mukhtaar |
| Person | Type | Job | Role(s) |
