| Person | Type | Job | Role(s) |
|---|---|---|---|
 Andrew Lazar | Crew | Production | Producer |
 Brad Peyton | Crew | Directing | Director |
Brent O'Connor | Crew | Production | Executive Producer |
 Bruce Berman | Crew | Production | Executive Producer |
Carol Lavallee | Crew | Art | Set Decoration |
 Christopher Lennertz | Crew | Sound | Original Music Composer |
Greg Michael | Crew | Directing | Second Unit Director |
Julie Rogers | Crew | Editing | Editor |
Ray McIntyre Jr. | Crew | Visual Effects | Stereoscopic Supervisor |
Rusty Smith | Crew | Art | Production Design |
Sandi Tanaka | Crew | Art | Art Direction |
Steve Bencich | Crew | Writing | Writer |
 Steven Poster | Crew | Camera | Director of Photography |
Tish Monaghan | Crew | Costume & Make-Up | Costume Design |
Jeremy Stewart | Crew | Visual Effects | Animation |
 Miri Yoon | Crew | Production | Co-Producer |
 Polly Johnsen | Crew | Production | Producer |
Ron J. Friedman | Crew | Writing | Writer |
Andy Hass | Crew | Visual Effects | Animation |
Seung Hoo Ihm | Crew | Visual Effects | Animation |
Sue Houston Safianoff | Crew | Visual Effects | Animation |
Nate Fredenburg | Crew | Art | Art Direction |
 Q Fortier | Crew | Visual Effects | Visual Effects |
 André Sogliuzzo | Cast | Actor | Snobby K-9 (voice) |
 Bette Midler | Cast | Actress | Kitty Galore (voice) |
 Betty Phillips | Cast | Actress | Cat Lady |
 Bumper Robinson | Cast | Actor | Cool Cat / Dog Killa / Cat Spy Analyst / Slim (voice) |
 Carlos Alazraqui | Cast | Actor | Cat Gunner / Cat Spy Analyst (voice) |
 Chris O'Donnell | Cast | Actor | Shane |
 Christina Applegate | Cast | Actress | Catherine (voice) |
 Elizabeth Daily | Cast | Actress | Scrumptious / Patches / Catherine's Niece (voice) |
 Fred Armisen | Cast | Actor | Freidrich |
 Grey DeLisle | Cast | Actress | Security Bulldog / Catherine's Niece / Cat Spy Analyst (voice) |
 Ingrid Tesch | Cast | Actress | Mom |
 J.K. Simmons | Cast | Actor | Gruff K-9 (voice) |
 James Marsden | Cast | Actor | Diggs (voice) |
 Jeff Bennett | Cast | Actor | Duncan MacDougall (voice) |
 Joe Pantoliano | Cast | Actor | Peek (voice) |
 Keith Dallas | Cast | Actor | Coit Tower Guard |
 Malcolm Stewart | Cast | Actor | Captain Flemming |
 Michael Beattie | Cast | Actor | Angus MacDougall (voice) |
 Michael Clarke Duncan | Cast | Actor | Sam (voice) |
 Neil Patrick Harris | Cast | Actor | Lou (voice) |
 Nick Nolte | Cast | Actor | Butch (voice) |
 Paul Rodríguez | Cast | Actor | Crazy Carlito (voice) |
 Phil LaMarr | Cast | Actor | Paws / Cat Spy Analyst (voice) |
 Roger L. Jackson | Cast | Actor | Inmate Fat Cat (voice) |
 Roger Moore | Cast | Actor | Tab Lazenby (voice) |
 Sean Hayes | Cast | Actor | Mr. Tinkles (voice) |
 Wallace Shawn | Cast | Actor | Calico (voice) |
 Christopher Lee Parson | Cast | Actor | Hep Cat / Cat Spy Analyst (voice) |
 Jack McBrayer | Cast | Actor | Chuck |
 Katt Williams | Cast | Actor | Seamus (voice) |
 Pascale Hutton | Cast | Actress | Jackie |
 Rick D. Wasserman | Cast | Actor | Rocky (voice) |
 Sage Brocklebank | Cast | Actor | Park Patron |
 Kiernan Shipka | Cast | Actress | Little Girl |
 Amitai Marmorstein | Cast | Actor | Playland Worker |
Len Morganti | Cast | Actor | Rex (voice) |
 Dawn Chubai | Cast | Actress | Reporter |
Mark Burgess | Cast | Actor | Used Car Salesman |
 Bonnie Cahoon | Cast | Actress | Dog HQ PA / Catherine's Niece (voice) |
Robert Hewko | Cast | Old Man | |
| Person | Type | Job | Role(s) |
